Bernard M Fischer

Recent Publications: (More Publications)

• , Auten RL, Potts EN, Mason SN, Fischer B, Huang Y, Foster WM. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. Am J Respir Crit Care Med. 2009 Dec 15; 180 (12) :1218-26. PubMed PMID:19762564; (2009)
• JA Voynow, BM Fischer, S Zheng, Proteases and cystic fibrosis., The international journal of biochemistry & cell biology (2008) [abs]
• BM Fischer, S Zheng, R Fan, JA Voynow, Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1., American journal of physiology. Lung cellular and molecular physiology, United States, vol 293 no. 3 (2007), pp. L762-8 [abs]
• S Zheng, AS Byrd, BM Fischer, AR Grover, AJ Ghio, JA Voynow, Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1., Free radical biology & medicine, United States, vol 42 no. 9 (2007), pp. 1398-408 [abs]
• JA Voynow, BM Fischer, BC Roberts, AD Proia, Basal-like cells constitute the proliferating cell population in cystic fibrosis airways., American journal of respiratory and critical care medicine, United States, vol 172 no. 8 (2005), pp. 1013-8 [abs]
• BM Fischer, JG Cuellar, AS Byrd, AB Rice, JC Bonner, LD Martin, JA Voynow, ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, United States, vol 19 no. 10 (2005), pp. 1374-6 [abs]
• JA Voynow, BM Fischer, DE Malarkey, LH Burch, T Wong, M Longphre, SB Ho, WM Foster, Neutrophil elastase induces mucus cell metaplasia in mouse lung., American journal of physiology. Lung cellular and molecular physiology, United States, vol 287 no. 6 (2004), pp. L1293-302 [abs]
• TM Krunkosky, LD Martin, BM Fischer, JA Voynow, KB Adler, Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors., Free radical biology & medicine, United States, vol 35 no. 9 (2003), pp. 1158-67 [abs]
• BM Fischer, JG Cuellar, ML Diehl, AM deFreytas, J Zhang, KL Carraway, JA Voynow, Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells., American journal of physiology. Lung cellular and molecular physiology, United States, vol 284 no. 4 (2003), pp. L671-9 [abs]
• BM Fischer, JA Voynow, Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species., American journal of respiratory cell and molecular biology, United States, vol 26 no. 4 (2002), pp. 447-52 [abs]
• TM Krunkosky, BM Fischer, LD Martin, N Jones, NJ Akley, KB Adler, Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression., American journal of respiratory cell and molecular biology, UNITED STATES, vol 22 no. 6 (2000), pp. 685-92 [abs]
• , Fischer BM, Voynow JA. Neutrophil elastase induces MUC5AC expression by an oxidant-dependent mechanism. Chest 117(May Supplement): 371S-320S, 2000. (2000)
• , Voynow JA, Fischer BM. Regulation of repiratory mucin gene expression by neutrophil elastase. In: Salathe, M (ED). Cilia, Mucus, and Mucociliary Interactions, Marcel Dekker, Inc., New York, NY, In Press, 2000. (2000)
• JA Voynow, LR Young, Y Wang, T Horger, MC Rose, BM Fischer, Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells., The American journal of physiology, UNITED STATES, vol 276 no. 5 Pt 1 (1999), pp. L835-43 [abs]
• BM Fischer, LG Rochelle, JA Voynow, NJ Akley, KB Adler, Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro., American journal of respiratory cell and molecular biology, UNITED STATES, vol 20 no. 3 (1999), pp. 413-22 [abs]
• , Voynow JA, Diehl ML, Fischer BM. Neutrophil elastase increases MUC4 gene expression by enhancing mRNA stability. Pediatric Pulmonology Suppl 19:257, 1999. (1999)
• LG Rochelle, BM Fischer, KB Adler, Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro., Free radical biology & medicine, UNITED STATES, vol 24 no. 5 (1998), pp. 863-8 [abs]
• , Adler KB, Fischer BM, Martin LD, Voynow JA. Effects of inflammatory mediators and drugs on mucus secretion and mucociliary function. Res. Immunol. 149: In Press, 1998. (1998)
• , Fischer BM, Li CM, Li HF, Choe NH, Wright DT, Rochelle LG, Adler KB. Intracellular regulation of mucin secretion in airway epithelial cells in vitro. In: Baum GL [ED]. International Congress on Cilia, Mucus and Mucociliary Interactions, Marcel Dekker, Inc., New York, NY. pp. 143-151, 1998. (1998)
• , Fischer BM, Scott S, Voynow JA. Reactive oxygen species mediate neutrophil elastase induced MUC5AC expression. Free Rad Biol Med 25 (Suppl 1):S49, 1998. (1998)
• , Fischer BM, Voynow JA. Neutrophil elastase induces MUC5AC mRNA expression by an oxidant-dependent mechanism. Pediatric Pulmonology Suppl 17:286, 1998. (1998)
• , Krunkosky TM, Fischer BM, Dodam J, Adler KB. Mechanisms of TNFa induced signaling in airway epithelium. Am J Resp Crit Care Med. 157(3): A198, 1998. (1998)
• , Voynow JA, Horger T, Fischer BM, Rose MC. Neutrophil elastase treatment increases MUC5/5AC glycoprotein levels in A549 cell lysates. Am J Resp Crit Care Med 157(3): A728, 1998. (1998)
• LD Martin, LG Rochelle, BM Fischer, TM Krunkosky, KB Adler, Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators., The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, DENMARK, vol 10 no. 9 (1997), pp. 2139-46 [abs]
• LD Martin, TM Krunkosky, JA Dye, BM Fischer, NF Jiang, LG Rochelle, NJ Akley, KL Dreher, KB Adler, The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates., Environmental health perspectives, UNITED STATES, vol 105 Suppl 5 (1997), pp. 1301-7 [abs]
• , Adler KB, Li C, Li H, Choe NH, Fischer BM. Intracellular regulation of mucin secretion. Presented at the International Congress on Cilia, Mucus and Mucociliary Interactions. 1997. (1997)
• , Chitano P, Fischer BM, Murphy TM. Maturational changes in the pattern of smooth muscle relaxation in guinea pig trachealis are not associated with changes of basal cyclic nucleotide content. Am J Resp Crit Care Med. 155:A56, 1997. (1997)
• , Cohn LA, Fischer BM, Krunkosky TM, Wright DT, and Adler KB. Airway epithelial cells in Asthma. In: Kay, AB [ED]. Allergy and Allergic Diseases, Blackwell Science, Ltd., Oxford, U.K. pages 263-283, 1997. (1997)
• , Fischer BM, Li C-M, Li H-F, Choe N-H, Wright DT, Rochelle LG, and Adler KB. Intracellular regulation of mucin secretion in airway epithelial cells in vitro. In: Baum GL [ED]. International Congress on Cilia, Mucus and Mucociliary Interactions, Marcel Dekker, Inc., New York, NY. In Press, 1997. (1997)
• , Krunkosky TM, Martin LD, Fischer BM, Adler KB. Mechanisms of TNFa induced ICAM-1 expression in airway epithelium. Am J Resp Crit Care Med. 155: A207, 1997. (1997)
• , Martin LD, Krunkosky TM, Dye JA, Fischer BM, Jiang NF, Rochelle LG, Akley NJ, Dreher KL, Adler KB. The Role of Reactive Oxygen and Nitrogen Species in theResponse of Airway Epithelium to Particulates Environ Health Perspect. 1997 Sep;105S(Suppl 5):1301-7. (1997)
• , Rochelle LG, Fischer BM, Boehm KA, Akley NJ, and Adler KB. Inflammatory mediators increase intracellular oxygen and nitrogen species (ROS/RNS) in airway epithelial cells. Am J Resp Crit Care Med. 155: A437, 1997. (1997)
• , Wright DT, Fischer BM, Li C, Yagaloff KA, and Adler KB. Interactions between oxidant gases and airway epithelium: In vitro-In vivo correlations. In: Dungworth DK, Adler KB, Harris CC, Plopper CG [ED]. Correlations between in vitro and in vivo investigations in inhalation toxicology. ILSI Press, Washington, D.C., pages 217-229, 1997. (1997)
• DT Wright, BM Fischer, C Li, LG Rochelle, NJ Akley, KB Adler, Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism., The American journal of physiology, UNITED STATES, vol 271 no. 5 Pt 1 (1996), pp. L854-61 [abs]
• TM Krunkosky, BM Fischer, NJ Akley, KB Adler, Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: possible signal transduction mechanisms., Annals of the New York Academy of Sciences, UNITED STATES, vol 796 (1996), pp. 30-7 [abs]
• LG Rochelle, BM Fischer, TM Krunkosky, DT Wright, KB Adler, Environmental toxins induce intracellular responses of airway epithelium through reactive species of oxygen and nitrogen. Roger S. Mitchell Lecture., Chest, UNITED STATES, vol 109 no. 3 Suppl (1996), pp. 35S-39S
• , Adler KB, Krunckosky TM, Fischer BM, Rochelle LG, Martin LD, Dreher KL, Jiang NF, Janice Dye. Role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates. Sixth International Meeting on the Toxicology of Natural and Man-made Fibrous and Non-fibrous Particles. 1966. (1996)
• , Adler KB, Wright DT, Fischer BM. Reactive oxygen species provoke secretion of mucin and activate phospholipase C in airway epithelial cells via a mechanism dependent on nitric oxide and hydroxyl free radical. Keystone Symposium on Molecular and Cellular Biology - Oxidant Stress: From molecules to man. 1996. (1996)
• , Fischer BM, Rochelle LG, Akley NJ, and Adler KB. Tumor necrosis factor-alpha (TNFa) induced mucin secretion: Dependence on nitric oxide (NO) and cyclic GMP. Am J Resp Crit Care Med. 153(4): A538, 1996. (1996)
• , Krunkosky TM, Fischer BM, Martin LD, Adler KB. Tumor necrosis factor alpha (TNFa) provokes expression of inercellular adhesion molecule-1 (ICAM-1) on human bronchial epithelial cells in primary culture. Am J Resp Crit Care Med. 153(4): A27, 1996. (1996)
• , Wright DT, Fischer BM, Li C-M, Rochelle LG, Akley NJ & Adler KB. Oxidant Stress stimulates mucin secretion and OLC in airways epithelium via nitric oxide-dependent mechanism. Amer J Physiol 271 (Lung Cell Mol Physiol 15): L854d-L861, 1996. (1996)
• KB Adler, BM Fischer, H Li, NH Choe, DT Wright, Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase., American journal of respiratory cell and molecular biology, UNITED STATES, vol 13 no. 5 (1995), pp. 526-30 [abs]
• BM Fischer, M Kreiselmeyer, J Schlegel, S Schadmand, S Iversen, HJ Rupprecht, J Lorenz, R Ferlinz, [Lung function in chronic persistent pulmonary embolism], Pneumologie (Stuttgart, Germany), GERMANY, vol 49 no. 4 (1995), pp. 273-6 [abs]
• BM Fischer, TM Krunkosky, DT Wright, M Dolan-O'Keefe, KB Adler, Tumor necrosis factor-alpha (TNF-alpha) stimulates mucin secretion and gene expression in airway epithelium in vitro., Chest, UNITED STATES, vol 107 no. 3 Suppl (1995), pp. 133S-135S
• , Fischer BM, Wright DT, Li H, Li C-M, Cohn LA, Akley NJ, and Adler KB. Endogenously-generated nitric oxide (NO) may be a key signaling molecule in hypersecretion of mucin by guinea pig tracheal epithelial (GPTE) cells in vitro. Am. J. Respir. Crit. Care Med. 151(4): A337, 1995. (1995)
• , Krunkosky TM, Fischer BM, Wright DT, Akley NJ, and Adler KB. Effects of tumor necrosis factor alpha (TNFa) on expression of ICAM-1 and inflammation-associated genes in airway epithelial cells in vitro. Am. J. Respir. Crit. Care Med. 151(4): A366, 1995. (1995)
• , Rochelle LG, Fischer BM, Wright DT, Li H-F, Choe N-H, Adler KB. NO may act as a critical signalliing molecule controlling mucin secretion by airway epithelial cells. 4th International Meeting of the Biology of Nitric Oxide, 1995. (1995)
• , Wright DT, Li C-M, Fischer BM, Akley NJ, and Adler KB. Reactive nitrogen species (RNS) stimulate secretion of mucin by primary cultures of guinea pig tracheal epithelial (GPTE) cells. Am. J. Respir. Crit. Care Med. 151(4): A337, 1995. (1995)
• KB Adler, BM Fischer, DT Wright, LA Cohn, S Becker, Interactions between respiratory epithelial cells and cytokines: relationships to lung inflammation., Annals of the New York Academy of Sciences, UNITED STATES, vol 725 (1994), pp. 128-45 [abs]
• , Adler KB, Fischer BM, Wright DT, Dolan-O'Keefe M. Effects of Tumor necrosis factor alpha (TNFa) on airway epithelial cells in vitro. Proceedings of the 8th International Colloquium on Lung Fibrosis: A3, 1994. (1994)
• , Adler KB, Wright DT, Fischer BM, Cohn LA, Li H, Li C, Choe NH, Akler NJ. Effects of oxidant stress on airway epithelial cells in vitro. FASEB J. 8: A896, 1994. (1994)
• , Wright DT, Akley NJ, Li H, Fischer BM and Adler KB. Reactive Oxidant Species (ROS) activate Phosphoplipase C in Guinea Pig and Human Airway Epithelial Cell In Vitro. Am. J Resp. & Crit. Care Med. 149: A315, 1994. (1994)
• , Wright DT, Cohn LA, Li H, Fischer BM, Li C, Adler KB. Interactions of oxygen radicals with airway epithelium. Environ. Health Perspect., 102 (Suppl. 10): 85-90, 1994. (1994)
• GS Price, RL Page, BM Fischer, JF Levine, TM Gerig, Efficacy and toxicity of doxorubicin/cyclophosphamide maintenance therapy in dogs with multicentric lymphosarcoma., Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, UNITED STATES, vol 5 no. 5, pp. 259-62 [abs]